SYSTEMATIC REVIEW OF PARENT AND FAMILY INTERVENTIONS Systematic Review and Meta-analysis: Parent and Family-Based Interventions for Children and Adolescents with Chronic Medical Conditions

Systematic review and meta-analysis of parent and family-based interventions for children and adolescents with chronic medical conditions. This version is made available in accordance with publisher policies. Please cite only the published version using the reference above. Abstract Objective: To quantify the effects of parent-and family-based psychological therapies for youth with common chronic medical conditions on parent and family outcomes (primary aim) and child outcomes (secondary aim). Thirty-seven randomized controlled trials were included. Quality of the evidence was evaluated using GRADE criteria. Data were extracted on parent, family, and child outcomes. Results: Pooled psychological therapies had a positive effect on parent behavior at post-treatment and follow-up; no significant improvement was observed for other outcome domains. Problem solving therapy (PST) improved parent mental health and parent behavior at post-treatment and follow-up. There was insufficient evidence to evaluate cognitive-behavioral and systems therapies for many outcome domains. Conclusions: Parent and family-based psychological therapies can improve parent outcomes, with PST emerging as particularly promising. Future research should incorporate consensus statements for outcomes assessment, multi-site recruitment, and active comparator conditions.